Sunitinib-induced pyoderma gangrenosum-like skin ulcer
نویسندگان
چکیده
منابع مشابه
Sunitinib induced pyoderma gangrenosum-like ulcerations
Pyoderma gangrenosum is a non-infectious neutro?philic skin disease commonly associated with underlying systemic diseases. Histopathological and laboratory diagnostics are unspecific in the majority of the cases and the diagnosis is made in accordance with the clinical picture. Here, we report the case of a 69-year old man with progredient pyoderma gangrenosum-like ulcerations under treatment w...
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710 started an oral ibrutinib therapy (3 × 140 mg/d), due to B-CLL. An ulcer biopsy revealed lymphocyte and neutrophil infiltration. No histopathologic signs of carcinoma or vasculitis were observed. After consultation with a hematologist, a tentative diagnosis of ibrutinib-induced pyoderma gangrenosum (PG) was established. In addition to ibrutinib discontinuation, daily prednisone dose was inc...
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Sir, The first published case of a Cryptococcus infection was reported by Zenker in 1861 (1), when he described a case of a man dying from a fungal infection involving the central nervous system (CNS). Thereafter, reports of Cryptococcus infections increased significantly. Today most cases occur in immunocompromised, often HIVinfected, individuals (2). C. neoformans (CN) is a ubiquitous yeast-l...
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The clinical management of pyoderma gangrenosum (PG) ulcers has been a challenging practice since the description of these chronic wounds. Advances in biotechnology in the past 2 decades have given us a better understanding of the histopathologic nature of this disease, and as a result, better therapeutic modalities have evolved. However, on occasion PG ulcers will present in a refractory manne...
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Pyoderma gangrenosum (PG) is an idiopathic, ulcerative, noninfective chronic inflammatory skin disorder of unknown etiology. It is associated with systemic medical illness in 50% of cases like inflammatory bowel disease, systemic arthritis, haematological diseases and malignancies. Characteristic lesions begin as pustule or vesiculopustule and progresses to an ulcer or deep erosion with violace...
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ژورنال
عنوان ژورنال: Canadian Medical Association Journal
سال: 2020
ISSN: 0820-3946,1488-2329
DOI: 10.1503/cmaj.191165